HOW SEDATIVE DRUGS IMPACT THE BRAIN – THE SCIENCE EXPLAINED

two. Histamine Receptor Antagonism: Some sedatives, like antihistamines, exert their sedative effects by blocking histamine receptors while in the brain, significantly H1 receptors. Histamine performs a task in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness.Nutritional supplements: Numerous health supplements —